Single Site - No Mutation Detected

This information is designed for individuals who have been tested for a hereditary cancer syndrome. It will help you understand the results of your test and is best reviewed with your healthcare provider. Please choose the link below that matches your test result by looking at the patient copy of your test result or contacting the healthcare provider who ordered your test.

The Genetic Test You Received

• Singe Site MELARIS ^®: Mutation-specific analysis for individuals with a known p16 mutation in the family.
  

Your Test Result

• No Mutation Detected

Overview of Your Test Result

Mutations in the p16 gene are the most common known cause of hereditary melanoma syndrome.

• One or more of your blood relatives was previously tested with MELARIS^® and a p16 mutation was identified.
• You were tested for this specific mutation and no mutation was detected.
• You did not inherit the p16 mutation that runs in your family.
• You do not have hereditary melanoma syndrome.*

* If you have a history of cancer on both your mother’s and father’s side of the family, you should talk to your healthcare provider about whether any additional genetic testing is appropriate.

Your Cancer Risks

Everyone has some chance of developing cancer. Your Single Site MELARIS^® test result indicates that you do not have hereditary melanoma syndrome. Your risk for melanoma by age 80 is approximately 2%, which is slightly increased over the 1% risk seen in the general population. Your risk of developing pancreatic cancer by age 80 is the same as the general population (approximately 1%). Your cancer risk may still be above average, due to other genetic, environmental, or lifestyle risk factors that may be present in your family. Talk to your healthcare provider about your specific risk profile.

Managing Your Risks

There are no general population screening guidelines for melanoma or pancreatic cancer. In general, you should:

• Perform regular skin self-exam for irregular moles or lesions. Report any worrisome moles or lesions promptly to your healthcare provider.
• Minimize exposure to the sun or ultraviolet radiation (for example: tanning beds). Wear sunscreen and protective clothing when going outside. Do not get sunburned.

Talk to your healthcare provider about the cancer screening options available to you.

It’s a Family Affair

• p16 mutations are passed on in a family.
• You had this genetic test because someone in your family had an identified p16 mutation.
  • You did not inherit the mutation that runs in your family.
  • Since you did not inherit the mutation, you cannot pass it on to your children and they do not need to be tested for the mutation.
• There may be other relatives in your family still at risk to have inherited the mutation who may want to consider Single Site MELARIS^® testing.
  • Your healthcare provider can assist you in determining which of your relatives should consider genetic testing.

If you need a copy of your genetic test result, please contact the healthcare provider who ordered your test.

Next Steps

Please work with your healthcare provider to determine the most appropriate next steps for you.

• Obtain a copy of your test result.
• Schedule consultations with appropriate healthcare providers.
• Create a plan for medical management.
• Consider sharing your genetic test result with your relatives.

Additional Resources

Myriad has resources available to help you with your genetic test result.

• Contact Myriad’s Medical Services Department at 1-800-469-7423 for:
  • Answers to questions about your test result.
  • Information about genetic testing for your relatives.
• Online tools:
  • List of Support Organizations
  • A healthcare provider who can offer genetic testing to relatives in any state can be found at the Find a Doctor page.
  • A sample letter that can be sent to relatives who may need genetic testing: letterME4SingleSite (Word)

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