Single Site - No Mutation Detected

This information is designed for individuals who have been tested for a hereditary cancer syndrome. It will help you understand the results of your test and is best reviewed with your healthcare provider. Please choose the link below that matches your test result by looking at the patient copy of your test result or contacting the healthcare provider who ordered your test.

Overview of Adenomatous Polyposis Syndromes

Mutations in APC and MYH cause most cases of adenomatous polyposis syndromes. These syndromes include familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP), and MYH-associated polyposis (MAP). These syndromes are associated with the development of varying numbers of adenomas (pre-cancerous polyps) in the colon and rectum. They also lead to an increase risk of colon/rectal (colorectal) cancer and, in some cases, other types of cancer.

The Genetic Test You Received

  • Singe Site COLARIS AP®: Mutation-specific analysis for individuals with a known APC or MYH gene mutation(s) in the family.

Your Test Result

  • Single Site - No Mutation Detected

Overview of Your Test Result

  • One or more of your blood relatives was previously tested with COLARIS AP® and a mutation(s) were identified in APC or MYH.
  • You were tested for the specific mutation(s) and no mutation(s) were detected.
  • You did not inherit the APC or MYH mutation(s) that runs in your family.
  • You do not have an adenomatous polyposis syndrome.*

* If you have a history of cancer on both your mother’s and father’s side of the family, you should talk to your healthcare provider about whether any additional genetic testing is appropriate.

Your Cancer Risks

Everyone has some chance of developing cancer. While your Single Site COLARIS AP® test result indicates that you do not have an adenomatous polyposis syndrome, you still have the general population risk to develop any type of cancer, including colorectal. Your cancer risk may still be above average, due to other genetic, environmental, or lifestyle risk factors that may be present in your family. Talk to your healthcare provider about your specific risk profile.

Cancer risks for the general population by age 70 General
Population
Colorectal cancer 2%
Duodenal cancer <1%
Pancreatic cancer <1%
Thyroid cancer <1%
Stomach cancer <1%

Managing Your Risks

Based on the American Cancer Society screening guidelines for colorectal cancer in individuals at average risk, you should begin one of the following at age 50:

  • Yearly fecal occult blood testing (FOBT) or fecal immunochemical test (FIT), OR
  • Flexible sigmoidoscopy every 5 years, OR
  • Yearly FOBT or FIT plus flexible sigmoidoscopy every 5 years, OR
  • Double contrast barium enema (DCBE) every 5 years, OR
  • Colonoscopy every 10 years

There are no general population screening guidelines for other cancers associated with adenomatous polyposis syndromes. Talk to your healthcare provider about the cancer screening options available to you.

It’s a Family Affair

  • APC and MYH mutations are passed on in a family.
  • You had this genetic test because someone in your family had an identified APC or MYH mutation(s).
    • You did not inherit the mutation(s) that runs in your family.
    • Since you did not inherit the mutation(s), you cannot pass it on to your children and they do not need to be tested for the mutation(s).
  • There may be other relatives in your family still at risk to have inherited the mutation(s) who may want to consider Single Site COLARIS AP® testing.
    • Your healthcare provider can assist you in determining which of your relatives should consider genetic testing.

If you need a copy of your genetic test result, please contact the healthcare provider who ordered your test.

Next Steps

Please work with your healthcare provider to determine the most appropriate next steps for you.

  • Obtain a copy of your test result.
  • Schedule consultations with appropriate healthcare providers.
  • Create a plan for medical management.
  • Consider sharing your genetic test result with your relatives.

Additional Resources

Myriad has resources available to help you with your genetic test result.

  • Contact Myriad’s Medical Services Department at 1-800-469-7423 for:
    • Answers to questions about your test result.
    • Information about genetic testing for your relatives.
  • Online tools:

« Back to the Results List
» Next Section: Cancer History Guide