Multisite 3 - No Mutation Detected

This information is designed for individuals who have been tested for a hereditary cancer syndrome. It will help you understand the results of your test and is best reviewed with your healthcare provider. Please choose the link below that matches your test result by looking at the patient copy of your test result or contacting the healthcare provider who ordered your test.

The Genetic Test You Received

  • Multisite 3 BRACAnalysis®: Analysis of the three most common BRCA1 and BRCA2 mutations in individuals of Ashkenazi Jewish ancestry.

Your Test Result

  • No Mutation Detected

Overview of Your Test Result

Mutations in BRCA1 and BRCA2 cause most cases of hereditary breast and ovarian cancer (HBOC), a syndrome that involves various cancers, primarily breast and ovarian.

  • Multisite 3 BRACAnalysis® is designed to detect three specific BRCA1 and BRCA2 mutations that explain the vast majority of HBOC syndromes in individuals with Ashkenazi (Eastern European) Jewish ancestry.
  • In your case none of these three mutations were detected.
  • Some individuals of Ashkenazi Jewish ancestry may have mutations other than the ones for which you were tested.
    • You could consider further testing with Comprehensive BRACAnalysis® (Reflex), a test that looks for these other mutations.
    • Talk about this possibility with your healthcare provider.

Your Cancer Risks

If No Mutation has been Previously Identified in Your Family:

  • The chance that you have HBOC syndrome is significantly reduced but not completely ruled out.
  • The possibility remains that your cancer risks could be increased.

If You had Multisite 3 BRACAnalysis® Because a Mutation was Previously Identified in Your Family:

  • You were tested for this specific mutation and the test was negative.
  • You did not inherit the BRCA1 or BRCA2 mutation that runs in your family.
    • You do not have HBOC syndrome.*
    • You are still at the general population risk to develop any type of cancer, including breast and ovarian.

* If you have a history of cancer on both your mother’s and father’s side of the family, you should talk to your healthcare provider about whether any additional genetic testing would be appropriate.

Managing Your Risks

If No Mutation has been Previously Identified in Your Family:

  • Your test result has given you some helpful information but it is still best to manage your cancer risks based on your personal and family history.
  • You and your healthcare provider can develop the most appropriate plan for your medical management.

If You had Multisite 3 BRACAnalysis® Because a Mutation was Previously Identified in Your Family:

  • There are general population screening guidelines for various cancers, including breast cancer.
  • Talk to your healthcare provider about your specific cancer risks and the options available to you.

It’s a Family Affair

If No Mutation has been Previously Identified in Your Family:

  • Most often, when no mutation is detected, your relatives would not be offered BRACAnalysis® testing.
  • In some cases, BRACAnalysis® testing should be offered to another relative who has been diagnosed with cancer. Talk to healthcare provider about this option.

If You had Multisite 3 BRACAnalysis® Because a Mutation was Previously Identified in Your Family:

  • BRCA1 and BRCA2 mutations are passed on in a family.
  • You had this genetic test because someone in your family had an identified BRCA1 or BRCA2 mutation.
    • You did not inherit the mutation that runs in your family.
    • Since you did not inherit the mutation, you cannot pass it on to your children and they do not need to be tested for the mutation.
  • There may be other relatives in your family still at risk to have inherited the mutation who may want to consider Multisite 3 BRACAnalysis® testing.
  • Your healthcare provider can assist you in determining which of your relatives should consider genetic testing.

If you need a copy of your genetic test result, please contact the healthcare provider who ordered your test.

Next Steps

Please work with your healthcare provider to determine the most appropriate next steps for you.

  • Obtain a copy of your test result.
  • Schedule consultations with appropriate healthcare providers.
  • Create a plan for medical management.
  • Ask your provider whether additional genetic testing makes sense for you or your family.
  • Share your genetic test result with your relatives.
  • Re-contact your healthcare provider on a regular basis for new information.

Additional Resources

Myriad has resources available to help you with your genetic test result.

  • Contact Myriad’s Medical Services Department at 1-800-469-7423 for:
    • Answers to questions about your test result.
    • Information about genetic testing for your relatives.
  • Online tools:

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