Single Site - No Mutation Detected

This information is designed for individuals who have been tested for a hereditary cancer syndrome. It will help you understand the results of your test and is best reviewed with your healthcare provider. Please choose the link below that matches your test result by looking at the patient copy of your test result or contacting the healthcare provider who ordered your test.

The Genetic Test You Received

  • Single Site BRACAnalysis®: Mutation-specific analysis for individuals with a previously identified BRCA1or BRCA2 mutation in the family.

Your Test Result

  • No Mutation Detected

Overview of Your Test Result

Mutations in BRCA1 and BRCA2 cause most cases of hereditary breast and ovarian cancer (HBOC), a syndrome that involves various cancers, primarily breast and ovarian.

  • One or more of your blood relatives was previously tested with BRACAnalysis® and either a BRCA1 or BRCA2 mutation was identified.
  • You were tested for this specific mutation and no mutation was detected.
  • You did not inherit the BRCA1 or BRCA2 mutation that runs in your family.
  • You do not have HBOC syndrome.*

* If you have a history of cancer on both your mother’s and father’s side of the family, you should talk to your healthcare provider about whether any additional genetic testing is appropriate.

Your Cancer Risks

Everyone has some chance of developing cancer. While your Single Site BRACAnalysis® test result indicates that you do not have HBOC syndrome, you still have the general population risk to develop any type of cancer, including breast and ovarian. Your cancer risk may still be above average, due to other genetic, environmental, or lifestyle risk factors that my be present in your family. Talk to your healthcare provider about your specific risk profile.

Cancer risks for the general population by age 70 General
Population
Breast cancer 7%
Ovarian cancer <2%
Male breast cancer .05%

Managing Your Risks

There are no general population screening guidelines for ovarian cancer. The American Cancer Society recommends the following screening guidelines for breast cancer in women at average risk.

  • Yearly mammograms starting at age 40 and continuing for as long as you are in good health.
  • Clinical breast exams (CBE) should be part of your periodic health exam, about every three years in your 20s and 30s and every year at 40 and over.
  • You should report any breast change promptly to your healthcare provider. Breast self-exam (BSE) is an option starting in your 20s.

Talk to your healthcare provider about the cancer screening options available to you.

It’s a Family Affair

  • BRCA1 and BRCA2 mutations are passed on in a family.
  • You had this genetic test because someone in your family had an identified BRCA1 or BRCA2 mutation.
    • You did not inherit the mutation that runs in your family.
    • Since you did not inherit the mutation, you cannot pass it on to your children and they do not need to be tested for the mutation.
  • There may be other relatives in your family still at risk to have inherited the mutation who may want to consider Single Site BRACAnalysis® testing.
    • Your healthcare provider can assist you in determining which of your relatives should consider genetic testing.

If you need a copy of your genetic test result, please contact the healthcare provider who ordered your test.

Next Steps

Please work with your healthcare provider to determine the most appropriate next steps for you.

  • Obtain a copy of your test result.
  • Schedule consultations with appropriate healthcare providers.
  • Create a plan for medical management.
  • Consider sharing your genetic test result with your relatives.

Additional Resources

Myriad has resources available to help you with your genetic test result.

  • Contact Myriad’s Medical Services Department at 1-800-469-7423 for:
    • Answers to questions about your test result.
    • Information about genetic testing for your relatives.
  • Online tools:

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