| Increasingly, direct genetic testing for germline
mutations in APC or MYH genes
is used to diagnose adenomatous polyposis
syndromes in those with a suggestive personal
or family history. Individuals who should
be offered genetic testing for adenomatous
polyposis syndromes are:32 |
 |
 |
Individuals who are clinically affected with FAP (100 or more colorectal
adenomas) |
 |
Individuals with "multiple" colorectal adenomas (usually 10 or more
cumulative adenomas) |
 |
Relatives of APC or MYH mutation
carriers, as appropriate |