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Increasingly, direct genetic testing for germline
mutations in APC or MYHgenes
is used to diagnose adenomatous polyposis
syndromes in those with a suggestive personal
or family history. Individuals who should
be offered genetic testing for adenomatous
polyposis syndromes are:32
Individuals who are clinically affected with FAP (100 or more colorectal
adenomas)
Individuals with "multiple" colorectal adenomas (usually 10 or more
cumulative adenomas)
Relatives of APC or MYHmutation
carriers, as appropriate
Genetic testing will allow you to identify patients with adenomatous
polyposis syndromes and then adjust their medical management accordingly.