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Melanoma Cancer Risks

Published Estimates of Cancer Risk for p16 Mutation Carriers

Site Population Risk1 Hereditary Risk
Melanoma
Risk of primary melanoma:

<1% by age 50
~1% by age 80		 Risk of primary melanoma:
50% by age 502
76% by age 802

Risk of second melanomas:
Increased risk for second melanomas in p16 mutation carriers previously diagnosed with one melanoma3,4
15% of patients with multiple primary melanomas (MPM) will have a mutation in the p16 gene4
Pancreatic <1% by age 75
Up to 17% by age 75 in some families5
  1. Ries LAG, Eisner MP, Kosary CL, Hankley BF, Miller BA, Clegg L, Edwards BK (eds). SEER Cancer Statistics Review, 1973-1999, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1973_1999/. Accessed December 30, 2002.
  2. Bishop DT, Demenais F, Goldstein AM, et al. Geographical variation in the penetrance of CDKN2A mutations for melanoma. J Natl Cancer Inst. 2002;94:894-903.
  3. Hashemi J, Platz A, Ueno T, Stierner U, Ringborg U, Hannson J. CDKN2A germline mutations in individuals with multiple cutaneous melanomas. Cancer Res. 2000;60:6864-6867.
  4. Monzon J, Liu L, Brill H, et al. CDKN2A mutations in multiple primary melanomas. N Engl J Med. 1998;338:879-887.
  5. Vasen HF, Gruis NA, Frants RR, van Der Velden PA, Hille ET, Bergman W. Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden). Int J Cancer. 2000;87:809-811.

» Managing Patients with Melanoma

MELARIS is a genetic test for hereditary melanoma
A genetic test for hereditary melanoma