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Hereditary Polyposis Syndromes
A polyposis syndrome is an inherited tendency to develop colorectal cancer, making your risk of cancer much higher than average. Families with the syndrome usually have 2 or more members who develop colorectal cancer, often before age 50.
About 5% to 10% of all cancers are caused by abnormal changes in the genetic code passed down from a parent. These changes are called inherited gene mutations. Polyposis syndromes are caused by mutations on the APC and/or MYH genes. The risk of colorectal cancer for people with these mutations is 80% to 100%.
Polyposis means many polyps
Polyps are small growths of tissue in the colon that usually are not cancerous. Certain polyps, called adenomatous polyps or adenomas, may lead to colorectal cancer. The presence of many adenomas is called adenomatous polyposis.
There are three polyposis syndromes that can be difficult to tell apart. With thorough examination, family history, and a COLARIS AP® genetic test, your healthcare provider may be able to determine which of the three syndromes is the likely cause of your family history of colorectal cancer.
Polyposis Syndromes
Risk of Developing Colorectal Cancer With or Without a Polyposis Syndrome (%)
