Once a diagnosis of Lynch syndrome is confirmed, appropriate treatment and management strategies can begin the process of reducing risk and improving outcomes. If a COLARIS® test result confirms the presence of a known deleterious mutation, the following medical management options may help reduce or even eliminate the risk of certain associated cancers.
Surgical Management of Colorectal Cancer
If colon cancer is diagnosed (or more than one advanced adenoma found) in a patient with Lynch syndrome, total colectomy with ileorectal anastomosis OR hemicolectomy are recommended54
In patients unwilling or unable to undergo periodic colonoscopy screening, prophylactic total colectomy with ileorectal anastomosis may be an option based on carrier status alone24,54
Surgical Management of Endometrial and Ovarian Cancer
Prophylactic total abdominal hysterectomy and bilateral salpingo-oophorectomy may be considered if colorectal cancer is detected
May also be considered when childbearing is concluded (especially if bleeding or other symptoms of uterine or ovarian disease occur)24,54
Increased Surveillance for Colorectal Cancer
Colonoscopy every 1-2 years beginning between age 20 and 25, OR 5-10 years before the earliest age of a patient’s family member diagnosed with colorectal cancer—whichever comes first
