TheraGuide 5-FU™ is the most comprehensive clinically available test for assessing the risk of toxicity due to 5-FU–based chemotherapy. It detects variations in 2 genes, dihydropyrimidine dehydrogenase (DPYD) and thymidylate synthetase (TYMS), that are responsible for a significant portion of serious adverse reactions to 5-FU–based therapy.1-4 One in 4 individuals carries variations in either of these genes. These variations are associated with up to a 60% risk of dose-limiting toxicity that is largely avoidable. TheraGuide 5-FU™ is a simple blood test that provides comprehensive analysis of DPYD and TYMS gene variations to predict and help prevent 5-FU–related adverse events.
References: 1. Morel A, Boisdron-Celle M, Fey L, et al. Clinical relevance of different dihydropyrimidine dehydrogenase gene single nucleotide polymorphisms on 5-fluorouracil tolerance. Mol Cancer Ther. 2006;5:2895-2904. 2. Lecomte T, Ferraz J-M, Zinzindohoué F, et al. Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res. 2004;10:5880-5888. 3. Pullarkat ST, Stoehlmacher J, Ghaderi V, et al. Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J. 2001;1:65-70. 4. Ichikawa W, Takahashi T, Suto K, et al. Orotate phosphoribosyltransferase gene polymorphism predicts toxicity in patients treated with bolus 5-fluorouracil regimen. Clin Cancer Res. 2006;12:3928-3934. 5. Schwab M, et al. Role of genetic and non-genetic factors for fluorouracil treatment related severe toxicity; a prospective clinical trial by the German 5-FU toxicity study group. J Clin Oncol, 2008.
[an error occurred while processing this directive]