5-FU–related toxicity has a major impact on patient care and costs
Implications of toxicity-
Although toxicity is often manageable, it can result in the following, which may affect efficacy, treatment time, and cost:
- Dose reductions
- Delays in treatment
- Changes or discontinuation of chemotherapy
- Interventions to address harmful side effects
- Hospitalization
Cost of management
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Interventions to address 5-FU–related toxicity can include:
- Fluid- and nutritional-replacement therapies
- Hematopoietic-stimulating therapies
- Antibiotic therapies
- Clinic and/or hospital visits
